Cili-CEF
Cili-CEF Cefixime Trihydrate USP Dry Powder for Oral Suspension USP is a 15ml (When reconstituted as directed). It is a 3rd generation oral cephalosporin antibiotic of 100mg cefixime per 5ml (when reconstituted as directed).
Cefixime is a semisynthetic, cephalosporin antibiotic intended for oral administration. Cefixime binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall synthesis, causing the inhibition of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by an autolysin inhibitor.
Package Contains: Each Cili-CEF package contains a 100mg Cefixime 15ml (When reconstituted as directed), 10ml sterile water vial, spoon & a leaflet. It is also available as a 200mg strength suspension and 400mg capsules.
Composition: 
Each teaspoonful (5ml) contains:
Cefixime trihydrate USP equivalent to Cefixime 100mg.
Directions for Reconstitution: Loosen the powder of the bottle. Add some sterile water (given in pack). Shake well & then add remaining sterile water into the bottle (shake well) to make up the required volume. SHAKE WELL BEFORE USE.
Dosage & Administration: Please see the directions circular. As directed by the physician.
Indications / Uses: Cili-CEF (Cefoxime) is indicated for the treatment of the following infections caused by susceptible strains of the designated microorganisms.
Middle Ear: Otitis media caused by S. pneumoniae, H. influenzae (beta-lactamase positive and negative strains), and B cararrhatis (beta-lactamase positive and negative strains) and S. pyogenes.
Paranasal Sinuses: Sinusitis caused by S pneumonia, H. influenza (beta-lactamase positive and negative strains) and B cararrhatis (beta-lactamase positive and negative strains).
Urinary Track: Acute uncomplicated cystitis and urethritis caused by E. coli, P. mirabitis, and Kiebsiella species.
Upper Respiratory Tract: Pharyngitis and tonsillitis caused by S. pyogenes.
Lower Respiratory Tract: Acute bronchitis caused by S. pneumoniae, B. catarrhalls (beta-lactamase positive and negative strains and H. influenzae (beta-lactamase positive and negative strains).
Uncomplicated Gonorrhoea: Incomplicated gonorrhoea (cervical/urethral and rectal) caused by N. gonorrhoea, including penicillinase (beta-lactamase-positive) and nonpenicillinase (beta-lactamase-negative) producing strains.
Dosage and administration: Children: The recommended dose of C-CEF suspension is 8 mg/kg/day of the suspension.
| Age | Cefixime/Day mg | Cill-CEF Suspension |
| 1-4 years | 100 | 1 teaspoonful |
| 5-9 Years | 200 | 2 teaspoonful |
| 5-1 Years | 300 | 3 teaspoonful |
The dosage in children aged 6 months to one year should be calculated on mg/kg basis. The safety and efficacy of Cefixime has not been established in children less than 6 months. Children weighing more than 50 kg or older than 12 years should be treated with the recommended adult dose. Elderly patients may be given as the same dose as recommended for adults.
Pediatric Use: Safety and effectiveness of Cefixime in children aged less than six months old have not been established.
Special Populations: Renal Impairment: Cefixime may be administered in the presence of impaired renal function. Normal dose and schedule may be employed in patients with creatinine clearance of 60 mL/min or greater. For more information, see the leaflet.
Contraindications: Cili-CEF (Cefixime) is contraindicated in patients with known allergy to the cephalosporin group of antibiotics.
Use in Pregnancy & Nursing Mothers: This drug should be used during pregnancy only if clearly needed. It is not known whether Cefixime is excreted in human milk. Consideration should be given to discontinuing nursing temporarily during treatment with this drug.
Side Effects: Pancytopenia, leukopenia, eosinophils, hemolytic anaemia, thrombocytopenia, thrombocytosis, prolongation in prothrombin time and bleeding coagulation disturbances. Agranulocytosis has also been rarely reported.
Hypersensitivity: Anaphylactic reaction including shock, internal swelling of the larynx with airways constriction, fever, serum sickness-like reactions, rash, urticaria, pruritus and inflammation of mucous membranes. Toxic epidermal necrolysis, Stevens-Johnson syndrome and erythema have also rarely been reported.
Ranal: Transient elevation in blood urea nitrogen (BUN), or creatinine and rare cases of renal failure and interstitial nephritis.
Hepatic: Hepatitis, jaundice, increases in alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatases, increase in bilirubin.
Gastrointestinal: Serious colitis (such as pseudomembranous colitis), diarrhoea, abdominal pain, vomiting, nausea, dyspepsia, anorexia and flatulence.
Others: Candidiasis, genital pruritus, vaginalis, headache, dizziness and hyperactivity.
Precautions: Patients should be counselled that antibacterial drugs, including Cefixime, should only be used to treat bacterial infections. They do not treat viral infections (common cold).
Drug Interactions: Warfarin and Anticoagulants. Increased prothrombin time with or without clinical bleeding has been reported when cefixime is administered concomitantly.
Over Dosage: There have been limited clinical experiences with overdose of cefixime. Symptoms of a cefixime overdose include nausea, vomiting, diarrhea, and abdominal cramps.
Warnings: Before therapy with Cefixime is instituted, careful inquiry should be made to determine whether the patients had previous reactions to cephalosporins, penicillins, or other drugs.
- Care should be exercised as the Anaphylactic/anaphylactoid reactions have been reported with the use of cefixime.
- Cefixime, should be administered cautiously to any patient who has demonstrated some form of allergy, particularly to drugs.
- Treatment with broad spectrum antibiotics, including Cefixime, alters the normal flora of the colon and tmay permit overgrowth of clostridia.
- Studies indicate that a toxin produced try Clostridium difficult is a primary cause of severe antibiotic-associated diarrhoea, including pseudomembranous colitis.
- Preudomembranous colitis has been reported with the use of Cefixime and other broad-spectrum antibiotics, it is important to consider this diagnosis in patients who develop diarrhoea in association with the use of antibiotics.
Instructions: 
Store at controlled room temperature (15°C -30°C).
Protect from heat, light and moisture.
Keep out of the reach of children.
To be sold & used under advice of a registered medical practitioner.
Avoid exposure to heat, sunlight & humidity.
Improper storage may deteriorate the medicine.
The reconstituted suspension should be kept 5-15°C so that the potency of the product remains stable and be used within 7days.
Replace cap securely after use.
Manufacturer & Buy Online:
Cili-CEF Suspension is manufactured by: Ipram INTERNATIONAL.
This is the link to the manufacturer: https://www.ipraminternational
You can buy it online at: https://pharmaservicesgroup.com
Or you can purchase it from any nearby pharmacy. It is currently (2026) available at a retail price of around 353-445 rupees.