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Esozole

Esozole (Esomeprazole) contains 14 capsules of 40 mg. It reduces the amount of acid produced in the stomach. ESOZOLE Capsule is an enteric-coated formulation of Esomeprazole Magnesium due to its acid-labile nature. Esomeprazole (Esozole) is the S-isomer of omeprazole, which inhibits gastric acid secretion more effectively than omeprazole. It decreases stomach acid, making the stomach less acidic.

Package Contains: Each Esozole package contains 14 capsules of 40mg & a leaflet. It is also available in 20mg capsules.

Composition:  Each Capsule Contains:  Esozole
Esomeprazole Magnesium Trihydrate Enteric Coated Pellets Eq. to Esomeprazole 40mg
(USP Specification)

Dosage: See package insert for full prescribing information or as directed by the physician.

Indications / Uses: Esozole capsules are indicated for:

  • Gastroesophageal Reflux Disease (GERD).
  • Treatment of Erosive Reflux Esophagitis.
  • Long-term management of patients with healed esophagitis to prevent relapse.
  • Symptomatic treatment of Gastroesophageal Reflux Disease (GERD) with out Esophagitis.
  • As triple therapy Esozole plus Amoxycillin and clarithromycin for the treatment of patients with H. Pylori infection and duodenal ulcer disease (active or history of within the past 5 year).
  • Healing of duodenal ulcer associated with Helicobacter pylori infection.
  • Prevention of relapse of peptic ulcers in patients with Helicobacter pylori-associated ulcers.

Dosage & Administration: Esozole Capsule should be swallowed whole and should be taken at least one hour before meals. Adult dosage guidelines for ESOMEPRAZOLE (Esozole) Capsule are given in table below:

RECOMMENDED ADULT DOSAGE GUIDELINES
INDICATION DOSE FREQUENCY
Healing of Erosive Esophagitis.

 

 20-40 mg

 

 Once daily for 4-8 weeks (An additional 4-8 week treatment may be considered if symptoms persist or esophagitis dose not heal).
Symptomatic treatment of Gastroesophageal Reflux Disease (GERD) without Esophagitis

 

 20-40 mg

 

 Once daily for 4 weeks (An additional 4-8 week treatment may be considered if symptoms persist & do not resolve completely).

 
H.Pylori eradication to reduce the risk of Duodenal ulcer recurrence: ESOZOLE (Esomeprazole)

(Amoxicillin)

(Clarithromycin)

 

  

 

40 mg

1000 mg

500 mg

 

  

 

Once daily for 10 days.

Twice daily for 10 days.

Twice daily for 10 days.

 

The drug should be used under strict medical supervision/advice.

Possible Adverse Effects / Side Effects: The most frequently occurring adverse events with Esomeprazole therapy include.

  • Diarrhea, nausea, flatulence, abdominal pain, constipation, and dry mouth.

Other side effects include:

  • Cardiovascular: Hypertension & tachycardia.
  • Gastrointestinal: Stomatitis and gastrointestinal candidiasis.
  • Nervous System/Psychiatric: Confusion, depression, Dizziness.
  • Endocrine: Gynaecomastia.
  • Hepatic: Increased liver enzymes, hepatitis with or without jaundice & hepatic failure.
  • Dermatologic: Rash, photosensitivity, toxic epidermal necrolysis (TEN), Stevens-Johnson syndrome, erythema multiforme & alopecia. Besides these, other adverse effects include malaise, hypersensitivity reactions like fever, bronchospasm, interstitial nephritis, increased sweating, peripheral edema, blurred vision, taste disturbance & hyponatraemia.

Contraindications: It is contraindicated in patients with known hypersensitivity to any component of the formulation or to substituted benzimidazoles.

Warning:

  • Use in Pregnancy: There are no well-controlled & adequate studies in pregnant women. It should be used during pregnancy only if clearly needed.
  • Use in Lactation: It is likely to be excreted in human milk, so esomeprazole should be used only if clearly needed.
  • Pediatric Use: Safety & effectiveness of the drug has not been established in pediatric patients.
  • Use in Elderly: No dosage adjustment required in elderly patients.
  • Use in Renal Failure: In case of severe renal failure, the drug should be used with caution.
  • Use in Hepatic Failure: Since the drug is extensively metabolized by hepatic cytochrome enzymes, so the drug should be used with caution in patients with hepatic insufficiency.

Instructions: Store at dry place below 30°C. Esozole back
Protect from heat, Sunlight & Moisture.
Keep all medicines out of the reach of Children.
To be sold on the prescription of RMP (registered medical practitioner) only.

Manufacturer & Buy Online:

Esozole capsules are manufactured by: Shazal’s Pharmaceuticals.

This is the link to the manufacturer: https://www.facebook.com

You can buy online at: https://medicalstore.com.pk

It is not available online, but you can buy it from any nearby pharmacy. It is currently (2026) available at the retail price of around 407 rupees.

It is available online, or you can buy it from any nearby pharmacy. It is currently (2026) available at the retail price of around 407 rupees.

 

By: Urooj

 

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