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Cyclogest

Cyclogest (Progesterone) is 400 mg, 15 pessaries. It is a vaginal/rectal tablet used to provide progesterone supplementation, particularly for supporting pregnancy during assisted reproductive technology (ART/IVF) treatment.

Package Contains: Each Cyclogest package contains 400mg of 15 pessaries (vaginal/rectal tablets) & a leaflet.

Composition: Each pessary contains 400 mg progesterone (Ph. Eur.)  Cyclogest

Suitable for vaginal or rectal use.

Dosage & Administration: As directed by the physician.

Cyclogest is used / Indicated for: Cyclogest contains micronised progesterone, which is a natural female sex hormone produced in the body. Cyclogest works by adjusting the hormonal balance within the body for:

  • treatment of pre-menstrual syndrome, including premenstrual tension and depression.
  • treatment of post-natal depression.
  • treatment of luteal phase defect in women who need extra progesterone, while undergoing treatment in an Assisted Reproductive Technology (ART) programme.

What you need to know before you use Cyclogest

Do not use Cyclogest if you:

  • Are allergic to progesterone or any of the other ingredients of this medicine (listed in section 6).
  • Have unusual vaginal bleeding that has not been evaluated by the doctor.
  • Have a known or suspected tumour that is hormone sensitive.
  • Have porphyria disorders (a group of inherited or acquired disorders of certain enzymes).
  • Have or have had blood clots in the legs, lungs, eyes or elsewhere in the body.
  • Currently have or have had severe liver problems.
  • Have had a miscarriage, and your physician suspects some tissue is still in the uterus or pregnancy outside of the womb.

Warnings and precautions:

  • Talk to your doctor, pharmacist or nurse before using Cyclogest.
  • Take special care and tell your doctor straight away if you experience any of these symptoms during treatment or even few days after the last dosage: pains in the calves or chest, a sudden shortness of breath or coughing blood indicating possible clots in the legs, heart, or lungs.
  • Severe headache or vomiting, dizziness, faintness, or changes in vision or speech, weakness or numbness of an arm or leg indicating possible clots in the brain or eye.
  • Worsening of depression.
  • Check with your doctor or pharmacist before using Cyclogest if you have or ever have had:
  • Liver problems such as jaundice (yellowing of the skin and whites of the eyes).
  • Epilepsy.
  • Migraine.
  • Asthma.
  • Cardiac or renal dysfunction.
  • Diabetes.

Children: There is no relevant use of Cyclogest in children.

Other medicines and Cyclogest: Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. This is especially important in case you are taking carbamazepine (e.g. to prevent fits, treat certain type of pain or mood disorders), rifampicin (to treat infections) or phenytoin (e.g. to prevent fits or treat certain type of pain) as they may decrease the effectiveness of progesterone.

Using other vaginal products at the same time as Cyclogest is used vaginally is not recommended, as it is not known if it affects the treatment.

Pregnancy and breast-feeding:

  • Cyclogest can be used during the first trimester of pregnancy for women who need extra progesterone while undergoing treatment in an Assisted Reproductive Technology (ART) programme.
  • The risks of congenital (conditions present at birth) anomalies, including genital abnormalities in male or female infants, from exposure to exogenous progesterone during pregnancy have not been fully established.
  • For other use, if you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.
  • This medicine should not be used during breastfeeding.

Uncommon side effects (may affect up to 1 in 100 people):

  • Headache, dizziness, mood changes.
  • Change in taste, vomiting, flatulence (wind), diarrhoea, bloat (gastric dilatation), rectal tumour.
  • Night sweats, skin rash or itching.
  • Joint pain.
  • Pelvic pain, ovarian enlargement, vaginal bleeding.
  • Frequent urination, involuntary excretion of urine.
  • Weight increase.
  • Bleeding.
  • Itching at the application site, feeling cold, body temperature change, or general discomfort.

Reporting of side effects: If you get any side effects, talk to your doctor, pharmacist, or nurse.

How to insert Cyclogest: Always wash your hands before and after inserting the pessary.

To insert into the:

  • Vagina– place the pessary between the lips of the vagina and push the pessary upwards and backwards. You may find it easier to do this if you are lying down or squatting.
  • Rectum (back passage) – gently push the pessary into the rectum for about one inch. Your muscles will do the pessary in place when it is far enough. Squeeze your buttocks together for a few seconds.

If you use more Cyclogest than you should:  If you (or someone else) have accidentally swallowed any of the pessaries or you use too many, contact your nearest hospital casualty department or your doctor immediately for advice.

If you forget to use Cyclogest: If you forget to insert a pessary, do so as soon as you remember, unless it is nearly time for the next dose. Never use two doses together. Remember to use the missed doses at the correct time.

If you stop using Cyclogest: Please consult your doctor or pharmacist for advice if you intend to stop or have stopped using Cyclogest. Abrupt discontinuation of progesterone dosing may cause increased anxiety, moodiness, and increased sensitivity to seizures. If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

Possible side effects: Like all medicines, this medicine can cause side effects, although not everyone gets them.

  • Stop using Cyclogest and contact your doctor at once if you have an allergic reaction. Signs may include a skin rash, which may be itchy.
  • Common (may affect up to 1 in 10 people): Drowsiness, abdominal discomfort or pain, breast pain.
  • Not known (frequency cannot be estimated from the available data): Diarrhoea, soreness in your rectum (back passage), flatulence (wind), changes in your menstrual cycle (you may find that your monthly period will start earlier than usual or it may be delayed), leakage after the pessary has dissolved (this is quite normal when using medicines that are inserted into the vagina or rectum).

Adverse reactions in patients undergoing ART treatment are presented below:

Common side effects (may affect up to 1 in 10 people):

  • Abdominal distension (swelling in the abdomen), abdominal pain, constipation.
  • Sleepiness.
  • This includes any possible side effects not listed in this leaflet. By reporting side effects, you can help provide more information on the safety of this medicine.

Instructions:  Cyclogest back

To be used only on medical advice.

See enclosed directions for use.

Keep out of the reach of children.

Store below 25°C in a cool and dry place.

Manufacturer & Buy Online:

Cyclogest pessary (vaginal/rectal tablets) is manufactured by: Accord-UK Ltd.

This is the link to the manufacturer: https://www.accord

Cyclogest is a trademark by: L.D. Collins & Co. Ltd.

This is the link to the trademark company: https://ldcollins

Cyclogest is solely agented and distributed by: Excel Healthcare Laboratories (Pvt) Ltd.

This is the link to the company: https://www.xlhealthcarelab

It is packed by: Apex Pharmaceuticals (Pvt) Ltd.

This is the link to the company: https://www.apexpharmapk

You can buy it online at:  https://meripharmacy.pk

You can buy it from any nearby pharmacy. It is currently (2026) available at the retail price of around 6985 rupees.

 

By: Urooj

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