Timosol

Timosol (Timolol 0.5%) by Schazoo is a sterile eye drops, 5ml.It is an anti-glaucoma drops for ophthalmic use only. It is a sterile, crystal clear anti-glaucomatous solution for topical use. Timolol maleate is a non-selective β-adrenoreceptor antagonist belonging to the phenoloxy propanolamine class of sympatholytic drugs.

It reduces the elevated intraocular pressure (IOP), which is a major risk factor in the pathogenesis of glaucomatous visual field loss and optic nerve damage.

Package Contains: Each Timosol package contains eye drops in a 5ml plastic dropper bottle & a leaflet.

Composition: Each ml contains:

Timolol (as maleate) U.S.P. 5 mg.

Benzalkonium chloride as preservative, Boric acid, Sodium borate, and WFI.

Mfg. U.S.P. Specs.

Dosage: As directed by the ophthalmologist.

Indication / Uses: Timosol sterile ophthalmic solution offers an effective, safe, convenient, and reliable therapy to normalize the consistently elevated IOP in the following pathological conditions:

Patients with ocular hypertension,
Patients with chronic open-angle glaucoma, including aphakic patients with glaucoma.
Patients with secondary glaucoma, e.g, steroid-induced and narrow-angle closure in the opposite eye.
Patients with narrow-angle of iatrogenically induced narrow-angle glaucoma.
Patients with paediatric glaucoma inadequately controlled with other anti-glaucomatous therapy in combination with miotics, adrenaline, or oral carbonic anhydrase inhibitors.

Contraindications: Timosol sterile ophthalmic solution is contraindicated in patients with:

Hypersensitivity to timolol maleate or benzalkonium chloride.
Sinus bradycardia, AV-block, overt cardiac failure, cardiogenic shock, and diabetes mellitus.
Bronchospasm, including bronchial asthma or severe chronic obstructive pulmonary disease.

Dosage & Administration: Usually, one to two drops of Timosol ophthalmic solution may be instilled in the eye(s) twice a day, but once the IOP is effectively controlled, the dosage may be reduced to one drop once a day.

Switching Over To Timosol: Add one drop of Timosol twice a day to the usual daily routine of the drug(s) already in use. On the next day, use only Timosol twice a day. When shifting from another topical ophthalmic ẞ-adrenergic blocking agent, that agent should be discontinued on one day and the treatment should be switched over to one drop of Timosol twice a day on the following day.

Children: One drop of Timosol every 12 hours in combination with other anti-glaucoma drugs.

Nursing Mothers: Because of the potential for serious adverse reactions from Timolol maleate in nursing infants, a decision should be made whether to continue nursing or to discontinue the drug, taking into consideration the importance of the therapy to mothers.

Side Effects: Timosol is generally well tolerated and is one of the safest drug used in glaucoma; however, the clinical trials have reported the following adverse effects;

Ocular irritation (conjunctivitis, blepharitis, keratitis), decreased corneal sensitivity and visual disturbances, including refractory changes due to withdrawal of miotics, diplopia and ptosis.
Aggravate certain cardio-pulmonary or other complications related to ẞ-blockers.
Rarely, cerebrovascular ischaemia and cerebrovascular accidents have been reported.
Other side effects include headache, nausea, dizziness, depression, fatigue, rash and urticaria.

Precautions/ Warnings: Timolol maleate may be absorbed into the bloodstream hence, it should be used with caution in patients with contraindications to the systemic use of β-blockers and patients with a history of pulmonary obstruction.

Timolol maleate may potentiate the effects of β-blockers in patients receiving β-adrenergic blocking agents either on IOP or on β-blockade, therefore a proper monitoring of the dosage is necessary.
When Timosol is used to reduce the elevated IOP in angle-closure glaucoma, it should be prescribed in combination with miotics.
In rare cases, with continuous use of Timosol, dryness of the eye(s) may occur. In such conditions, the drug should be discontinued and all β-blockers should be withdrawn gradually.
The use of Timolol maleate is not recommended in premature infants and neonates.
The use of Timolol in pregnancy has not been established so far.

Drug Interactions: In monotherapy, timolol maleate has little or no effect on pupil size; mydriasis may occasionally result from concomitant therapy with epinephrine.

The potential exists for agonistic effects leading to hypotension when Timosol is administered together with an oral calcium channel blocker, β-blocker and catecholamine-depleting drugs.

DIRECTIONS: Store in a cool and dry place. Protect from heat, light & moisture. Keep all medicines out of the reach of children. Keep bottle tightly closed when not in use. Contact lenses should be removed during the treatment. Use under strict medical supervision.

Manufacturer & Buy Online:

Timosol eye drops are manufactured by: The Schazoo Pharmaceutical Laboratories (Pvt) Ltd.

This is a link to the manufacturer at: https://schazoo-spl.com

You can buy this medicine online at: https://nmp.com.pk